Hybrid$^2$ Neural ODE Causal Modeling and an Application to Glycemic Response

Hybrid models composing mechanistic ODE-based dynamics with flexible and expressive neural network components have grown rapidly in popularity, especially in scientific domains where such ODE-based modeling offers important interpretability and validated causal grounding (e.g., for counterfactual reasoning). The incorporation of mechanistic models also provides inductive bias in standard blackbox modeling approaches, critical when learning from small datasets or partially observed, complex systems. Unfortunately, as the hybrid models become more flexible, the causal grounding provided by the mechanistic model can quickly be lost. We address this problem by leveraging another common source of domain knowledge:rankingof treatment effects for a set of interventions, even if the precise treatment effect is unknown. We encode this information in acausal lossthat we combine with the standard predictive loss to arrive at ahybrid lossthat biases our learning towards causally valid hybrid models. We demonstrate our ability to achieve a win-win, state-of-the-art predictive performanceandcausal validity, in the challenging task of modeling glucose dynamics post-exercise in individuals with type 1 diabetes.